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叶瑞东，毕业于第四军医大学，获神经病学博士学位。美国罗彻斯特大学访问学者。现任东部战区总医院神经内科病区主任、副主任医师、副教授、色情动漫 博士生导师。 长期致力于脑血管病的临床和基础研究，入选江苏省青年医学重点人才，江苏省“333”高层次人才。获得江苏省科技进步二等奖1项（1/9），教育部科技进步二等奖1项（2/11）。参与起草《脑血管造影术操作规范中国专家共识》、《中国急性缺血性脑卒中早期血管内介入诊疗指南2018、2022》等行业规范文件。主持国家自然科学基金3项，江苏省重点研发计划等课题3项。累计发表论文50余篇，包括Journal of Clinical Investigation、Nature Communications、Lancet Neurology等一区期刊。 1) 中国卒中学会神经介入分会，第三届，委员，2025-2028 2) 江苏省卒中学会脑再灌注与代谢专委会，第一届，副主委，2025-2029 3) 江苏省医学会脑卒中分会，第三届，委员，2023-2025 4) 江苏省卒中学会基础与转化医学专委会，第一、二届，委员，2017-2027 5) 中国卒中学会神经介入分会青委会，第二届，委员，2019-2023 6) 江苏省卒中学会青委会，第一届，副主委，2018-2022
2) Zhao Y, Zhu W, Wan T, Zhang X, Li Y, Huang Z, Xu P, Huang K, Ye R*, Xie Y*, Liu X*. Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice. Nat Commun. 2022, 13(1):6813. 3) Xu X, Huang F, Shi X, Liu R, Han Y, Li M, Wang F, Yang Q, Zhu W, Ye R*, Liu X*. Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy. Front Neurosci. 2022; 16: 861511. 4) Wang L, Zhao Y, Gang S, Geng T, Li M, Xu L, Zhang X, Liu L, Xie Y*, Ye R*, Liu X. Inhibition of miR-103-3p preserves neurovascular integrity through caveolin-1 in experimental subarachnoid hemorrhage. Neuroscience. 2021, 461:91-101. 5) Xie Y, Zhang X, Xu P, Zhao N, Zhao Y, Li Y, Hong Y, Peng M, Yuan K, Wan T, Sun R, Chen D, Xu L, Chen J, Guo H, Shan W, Li J, Li R, Xiong Y, Liu D, Wang Y, Liu G, Ye R*, Liu X*. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia. J Clin Invest. 2021, 131(1):e128114. 7) Shi X, Cai H, Wang F, Liu R, Xu X, Li M, Han Y, Yin Q, Ye R*, Liu X*. Cholesterol Crystals are Associated with Carotid Plaque Vulnerability: An Optical Coherence Tomography Study. J Stroke Cerebrovasc Dis. 2020;29(2):104579. 8) Shi X, Gao J, Lv Q, Cai H, Wang F, Ye R*, Liu X*. Calcification in Atherosclerotic Plaque Vulnerability: Friend or Foe? Front Physiol. 2020; 11: 56. 9) Xu L, Cao H, Xie Y, Zhang Y, Du M, Xu X, Ye R*, Liu X*. Exosome-shuttled miR-92b-3p from ischemic preconditioned astrocytes protects neurons against oxygen and glucose deprivation. Brain Res. 2019;1717:66-73. 10) Zuo M, Guo H, Wan T, Zhao N, Cai H, Zha M, Xiong Y, Xie Y, Ye R*, Liu X*. Wallerian degeneration in experimental focal cortical ischemia. Brain Res Bull. 2019;149:194-202. 11) Wang L, Li M, Xie Y, Xu L, Ye R*, Liu X*: Preclinical efficacy of human Albumin in subarachnoid hemorrhage. Neuroscience 2017;344:255-264. 12) Xie Y, Guo H, Wang L, Xu L, Zhang X, Yu L, Liu Q, Li Y, Zhao N, Zhao N, Ye R*, Liu X*: Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage. Brain Behav Immun. 2016; (16)346-360. 13) Zhang J, Zhu W, Xiao L, Cao Q, Zhang H, Wang H, Ye Z, Hao Y, Dai Q, Sun W, Xiong Y, Liu X, Ye R*, Xu G*: Lower serum caveolin-1 is associated with cerebral microbleeds in patients with acute ischemic stroke. Oxid Med Cell Longev 2016; 9026787. 14) Ye R*, Shi M, Liu Q, Chen J: Redox imbalance and stroke. Oxid Med Cell Longev 2016; 3065263. IF: 4.492 15) Xu L, Wang L, Wen Z, Wu L, Jiang Y, Yang L, Xiao L, Xie Y, Ma M, Zhu W, Ye R*, Liu X*: Caveolin-1 is a checkpoint regulator in hypoxia-induced astrocyte apoptosis via ras/raf/erk pathway. Am J Physiol Cell Physiol 2016;310:C903-910. 16) Guo Z, Yu S, Chen X, Ye R*, Zhu W*, Liu X: Nlrp3 is involved in ischemia/reperfusion injury. CNS Neurol Disord Drug Targets 2016;15:699-712. 17) Xie Y, Liu W, Zhang X, Wang L, Xu L, Xiong Y, Yang L, Sang H, Ye R*, Liu X*: Human albumin improves long-term behavioral sequelae after subarachnoid hemorrhage through neurovascular remodeling. Crit Care Med 2015;43:e440-449. 18) Xu L, Guo R, Xie Y, Ma M, Ye R*, Liu X: Caveolae: Molecular insights and therapeutic targets for stroke. Expert Opin Ther Targets 2015;19:633-650. 19) Huang Z, Zhang X, Zhang H, Ye R*, Xiong Y, Sun W, Li Y, Liu X*: Reduced endothelial progenitor cells in extracranial arterial stenosis but not intracranial arterial stenosis. J Vasc Surg 2015;62:1539-1545. 20) Liu X#*, Ye R#, Yan T, Yu SP, Wei L, Xu G, Fan X, Jiang Y, Stetler RA, Liu G, Chen J*: Cell based therapies for ischemic stroke: From basic science to bedside. Prog Neurobiol 2014;115:92-115. 21) Kong X#, Liu Y#, Ye R#, Zhu B, Zhu Y, Liu X, Hu C, Luo H, Zhang Y, Ding Y*, Jin Y*: Gsk3beta is a checkpoint for tnf-alpha-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments. Biochim Biophys Acta 2013;1830:5119-5129. 22) Ye R, Zhao G, Liu X*: Ginsenoside rd for acute ischemic stroke: Translating from bench to bedside. Expert Rev Neurother 2013;13:603-613. 23) Ye R, Yang Q, Kong X, Li N, Zhang Y, Han J, Xiong L, Liu X, Zhao G*: Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: Role of mitochondrial permeability transition. Crit Care Med 2012;40:2685-2693. 24) Li N, Kong X, Ye R*, Yang Q, Han J, Xiong L: Age-related differences in experimental stroke: Possible involvement of mitochondrial dysfunction and oxidative damage. Rejuvenation Res 2011;14:261-273. 25) Ye R, Kong X, Yang Q, Zhang Y, Han J, Li P, Xiong L, Zhao G*: Ginsenoside rd in experimental stroke: Superior neuroprotective efficacy with a wide therapeutic window. Neurotherapeutics 2011;8:515-525. 26) Ye R, Kong X, Yang Q, Zhang Y, Han J, Zhao G*: Ginsenoside rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice. Neuropharmacology 2011;61:815-824. 27) Ye R, Zhang X, Kong X, Han J, Yang Q, Zhang Y, Chen Y, Li P, Liu J, Shi M, Xiong L, Zhao G*: Ginsenoside rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia. Neuroscience 2011;178:169-180. 28) Ye R, Yang Q, Kong X, Han J, Zhang X, Zhang Y, Li P, Liu J, Shi M, Xiong L, Zhao G*: Ginsenoside rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats. Neurochem Int 2011;58:391-398. 29) Ye R, Li N, Han J, Kong X, Cao R, Rao Z, Zhao G*: Neuroprotective effects of ginsenoside rd against oxygen-glucose deprivation in cultured hippocampal neurons. Neurosci Res 2009;64:306-310. 30) Ye R, Kong X, Han J, Zhao G*: N-methyl-d-aspartate receptor antagonists for migraine: A potential therapeutic approach. Med Hypotheses 2009;72:603-605. 31) Ye R, Han J, Kong X, Zhao L, Cao R, Rao Z, Zhao G*: Protective effects of ginsenoside rd on pc12 cells against hydrogen peroxide. Biol Pharm Bull 2008;31:1923-1927.
参与作者 1) Huang K, Yao W, Zha M, Qin S, Li Y, Xu Y, Liu R, Ye R, Han Y, Zhu W, Teng Z, Du J, Liu X. Angiography-based hemodynamic features predict recurrent ischemic events after angioplasty and stenting of intracranial vertebrobasilar atherosclerotic stenosis. Eur Radiol. 2023. 2) Wan T, Zhu W, Zhao Y, Zhang X, Ye R, Zuo M, Xu P, Huang Z, Zhang C, Xie Y, Liu X. Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice. Nat Commun. 2022;13(1):1134. 3) Zhang X, Gong P, Zhao Y, Wan T, Yuan K, Xiong Y, Wu M, Zha M, Li Y, Jiang T, Liu X, Ye R, Xie Y, Xu G. Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury. EBioMedicine. 2022; 84:104275. 4) Peng M, Sun R, Hong Y, Wang J, Xie Y, Zhang X, Li J, Guo H, Xu P, Li Y, Wang X, Wan T, Zhao Y, Huang F, Wang Y, Ye R, Liu Q, Liu G, Liu X, Xu G. Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations. Cell Mol Life Sci. 2022; 79(8):430. 5) Liu X, Dai Q, Ye R, Zi W, Liu Y, Wang H, Zhu W, Ma M, Yin Q, Li M, Fan X, Sun W, Han Y, Lv Q, Liu R, Yang D, Shi Z, Zheng D, Deng X, Wan Y, Wang Z, Geng Y, Chen X, Zhou Z, Liao G, Jin P, Liu Y, Liu X, Zhang M, Zhou F, Shi H, Zhang Y, Guo F, Yin C, Niu G, Zhang M, Cai X, Zhu Q, Chen Z, Liang Y, Li B, Lin M, Wang W, Xu H, Fu X, Liu W, Tian X, Gong Z, Shi H, Wang C, Lv P, Tao Z, Zhu L, Yang S, Hu W, Jiang P, Liebeskind DS, Pereira VM, Leung T, Yan B, Davis S, Xu G, Nogueira RG; BEST Trial Investigators. Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol. 2020;19(2):115-122. 6) Juan Du, Yao W, Li J, Yang F, Hu J, Xu Q, Liu L, Lv Q, Liu R, Ye R, Ma M, Zhu W, Zhang Z, Liu X. Motor Network Reorganization After Repetitive Transcranial Magnetic Stimulation in Early Stroke Patients: A Resting State fMRI Study. Neurorehabil Neural Repair. 2022;36(1):61-68. 7) Xu X, Li M, Liu R, Yin Q, Shi X, Wang F, Gao J, Xu G, Ye R, Liu X. Optical coherence tomography evaluation of vertebrobasilar artery stenosis: case series and literature review. J Neurointerv Surg. 2020. 12(8):809-813. 8) Xiao L, Ma M, Gu M, Han Y, Wang H, Zi W, Yang D, Hao Y, Lv Q, Ye R, Sun W, Zhu W, Xu G, Liu X; ACTUAL Investigators. Renal impairment on clinical outcomes following endovascular recanalization. Neurology. 2020;94(5):e464-e473. 9) Liu R, Yin Q, Li M, Ye R, Zhu W, Liu X. Diagnosis and treatment evaluation of in-stent restenosis of carotid artery stenting using optical coherence tomography. Neurology. 2019; 92(2): 99-100. 10) Zhang J, Cao Q, Li R, Hu J, Dai J, Zhang H, Wang H, Yang F, Ye R, Liu X, Xu G. Hemodynamic responses to magnetic stimulation of carotid sinus in normotensive rabbits. J Hypertens 2017;35(8):1676-1684. 11) Sang H, Qiu Z, Cai J, Lan W, Yu L, Zhang H, Li M, Xie Y, Guo R, Ye R, Liu X, Liu L, Zhang R. Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats. Transl Stroke Res 2017;8(6):597-611. 12) Du J, Tian L, Liu W, Hu J, Xu G, Ma M, Fan X, Ye R, Jiang Y, Yin Q, Zhu W, Xiong Y, Yang F, Liu X: Effects of repetitive transcranial magnetic stimulation on motor recovery and motor cortex excitability in patients with stroke: a randomized controlled trial. Eur J Neurol 2016;23(11):1666-1672. 13) Guo Z, Yu S, Xiao L, Chen X, Ye R, Zheng P, Dai Q, Sun W, Zhou C, Wang S, Zhu W, Liu X: Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke. J Neuroinflammation 2016;13:199. 15) Cao Q, Pei P, Zhang J, Naylor J, Fan X, Cai B, Dai Q, Sun W, Ye R, Shi R, Liu K, Jiang Y, Liu W, Yang F, Zhu W, Xiong Y, Liu X, Xu G: Hypertension unawareness among chinese patients with first-ever stroke. BMC Public Health 2016;16:170. 18) Xu G, Zhang Z, Lv Q, Li Y, Ye R, Xiong Y, Jiang Y, Liu X: Nsfc health research funding and burden of disease in china. PLoS One 2014;9:e111458. 19) Xiao L, Sun W, Lan W, Xiong Y, Duan Z, Zhang Z, Fan W, Xu L, Xie X, Ma N, Ye R, Xu G, Liu X, Zhu W: Correlation between cerebral microbleeds and s100b/rage in acute lacunar stroke patients. J Neurol Sci 2014;340:208-212. 20) Lv Q, Lan W, Sun W, Ye R, Fan X, Ma M, Yin Q, Jiang Y, Xu G, Dai J, Guo R, Liu X: Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats. J Neurol Sci 2014;345:48-55. 21) Chen Z, Ye R, Goldman SA: Testosterone modulation of angiogenesis and neurogenesis in the adult songbird brain. Neuroscience 2013;239:139-148. 22) Zhang C, Du F, Shi M, Ye R, Cheng H, Han J, Ma L, Cao R, Rao Z, Zhao G: Ginsenoside rd protects neurons against glutamate-induced excitotoxicity by inhibiting ca(2+) influx. Cell Mol Neurobiol 2012;32:121-128. 23) Liu J, Yan X, Li L, Zhu Y, Qin K, Zhou L, Sun D, Zhang X, Ye R, Zhao G: Ginsennoside rd attenuates cognitive dysfunction in a rat model of alzheimer's disease. Neurochem Res 2012;37:2738-2747. 24) Yang Q, Dong H, Deng J, Wang Q, Ye R, Li X, Hu S, Xiong L: Sevoflurane preconditioning induces neuroprotection through reactive oxygen species-mediated up-regulation of antioxidant enzymes in rats. Anesth Analg 2011;112:931-937. 25) Liu J, Lin T, Yan X, Jiang W, Shi M, Ye R, Rao Z, Zhao G: Effects of infrasound on cell proliferation in the dentate gyrus of adult rats. Neuroreport 2010;21:585-589.
1) 星形胶质细胞LCN2介导脑缺血远隔部位白质损伤的机制研究，国家自然科学基金面上项目。 2) 脑血流储备功能的多模态影像评估技术研究，江苏省重点研发计划（社会发展面上项目）。 3) 江苏省青年医学人才，江苏省卫计委。 4) 自发性动脉粥样硬化性脑缺血模型的建立与应用，国家自然科学基金面上项目。 5) 线粒体生物发生在七氟醚预处理诱导神经保护中的作用及调控机制，国家自然科学基金青年科学基金项目。 1) 急性大血管闭塞性脑卒中的血管再通治疗。2022年江苏省科学技术进步奖二等奖，排名第1，证书号2022-2-77-R1。 2) 脑血管病介入诊疗新技术的研究与应用。2018年教育部科学技术进步奖二等奖，排名第2，证书号2018-244。 3) 基于脑血管结构和功能评估的缺血性卒中的介入治疗。2017军队科技进步一等奖，排名第8，证书号2016140510170001。 4) 中药单体甾体皂甙治疗缺血性脑卒中的临床应用。2015年全军医疗成果二等奖，排名第6，证书号2015-2-42-7。 5) 人参皂苷Rd治疗急性缺血性脑卒中的临床研究。2012年中国中西医结合学会科学技术奖二等奖，排名第7，证书号2012-94-1B。 |
